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Daftar Kandidat Vaksin COVID-19 yang Sedang di Uji Klinik di Seluruh Dunia

farmasetika.com 27 April 2020 Uji Klinik Leave a comment

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Majalah Farmasetika – Pengembangan vaksin untuk COVID-19 sedang berlangsung, dengan banyak kandidat vaksin sedang dipelajari dalam uji klinis. Apoteker adalah penyedia perawatan kesehatan di garis depan dalam respons negara terhadap COVID-19. Asosiasi Apoteker Amerika (American Pharmacists Association) merilis 11 daftar kandidat vaksin COVID-19 hingga 13 April 2020.

Di negara maju termasuk Amerika Serikat, Apoteker dapat memainkan peran kunci dalam memberikan imunisasi terhadap virus SARS-CoV-2, ketika vaksin tersedia. Berikut adalah daftarnya :

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Merujuk dari data clinicaltrials.gov per 27 April 2020, total 18 uji klinik sedang dan akan dilakukan.

Row	Status	Study Title	Conditions	Interventions	Outcome Measures	Number Enrolled	Locations
1	Recruiting	Safety and Immunity of Covid-19 aAPC Vaccine	Treat and Prevent Covid-19 Infection	Biological: Pathogen-specific aAPC	Frequency of vaccine events Frequency of serious vaccine events Proportion of subjects with positive T cell response (and 6 more…)	100	Shenzhen Geno-immune Medical Institute Shenzhen, Guangdong, China
2	Recruiting	Immunity and Safety of Covid-19 Synthetic Minigene Vaccine	Pathogen Infection Covid-19 Infection	Biological: Injection and infusion of LV-SMENP-DC vaccine and antigen-specific CTLs	Clinical improvement based on the 7-point scale Lower Murray lung injury score 28-day mortality (and 7 more…)	100	Shenzhen Geno-immune Medical Institute Shenzhen, Guangdong, China Shenzhen Second People’s Hospital Shenzhen, Guangdong, China Shenzhen Third People’s Hospital Shenzhen, Guangdong, China
3	Not yet recruiting NEW	Application of BCG Vaccine for Immune-prophylaxis Among Egyptian Healthcare Workers During the Pandemic of COVID-19	Coronavirus Disease (COVID-19)	Biological: intradermal injection of BCG Vaccine Other: placebo	incidence of confirmed COVID-19 Effectiveness of BCG vaccine	900	Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center Cairo, Non-US, Egypt
4	Recruiting NEW	Reducing Health Care Workers Absenteeism in Covid-19 Pandemic Through BCG Vaccine	COVID-19	Drug: BCG Vaccine Drug: Placebo	Health Care Workers absenteeism The cumulative incidence of documented SARS-CoV-2 infection The number of days of unplanned absenteeism, because of documented SARS-CoV-2 infection (and 13 more…)	1500	Jeroen Bosch ziekenhuis Den Bosch, Brabant, Netherlands Canisius Wilhelmina Ziekenhuis Nijmegen, Gelderland, Netherlands Radboud UMC Nijmegen, Gelderland, Netherlands (and 6 more…)
5	Recruiting NEW	Safety and Immunogenicity Study of 2019-nCoV Vaccine (Inactivated) for Prophylaxis SARS CoV-2 Infection (COVID-19)	COVID-19	Biological: Two doses of medium dosage inactivated SARS-CoV-2 vaccine at the emergency vaccination schedule Biological: Two doses of high dosage inactivated SARS-CoV-2 vaccine at the emergency vaccination schedule Biological: Two doses of placebo at the emergency vaccination schedule (and 3 more…)	Safety indexes of adverse reactions Immunogenicity indexes of neutralizing-antibody seroconversion rates for the emergency vaccination schedule （day 0,14） Immunogenicity indexes of neutralizing-antibody seroconversion rates for the routine vaccination schedule (day 0,28) (and 7 more…)	744	Suining County Center for Disease Control and Prevention Xuzhou, Jiangsu, China
6	Not yet recruiting NEW	Measles Vaccine in HCW	Covid19	Drug: Measles-Mumps-Rubella Vaccine	COVID-19 disease incidence SARS-CoV-2 pneumonia Critical care admission duration with SARS-CoV-2 Oxygen therapy with SARS-CoV-2	200	Cairo University Hospital Cairo, Egypt
7	Not yet recruiting NEW	Performance Evaluation of BCG vs COVID-19	COVID-19	Biological: vaccine BCG Other: Placebo	Primary outcome Secondary outcome	1000	Program for Research and Control in Tropical Diseases – PECET Medellín, Antioquia, Colombia
8	Recruiting NEW	BCG Vaccination to Protect Healthcare Workers Against COVID-19	Coronavirus Disease 2019 (COVID-19) Febrile Respiratory Illness Corona Virus Infection COVID-19	Drug: BCG Vaccine	COVID-19 disease incidence Severe COVID-19 disease incidence COVID-19 incidence by 12 months (and 29 more…)	4170	Epworth Victoria Parade Melbourne, Victoria, Australia Royal Children’s Hospital Melbourne, Victoria, Australia Epworth Richmond Melbourne, Victoria, Australia (and 5 more…)
9	Active, not recruiting	Phase I Clinical Trial of a COVID-19 Vaccine in 18-60 Healthy Adults	COVID-19	Biological: Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector)	Safety indexes of adverse reactions Safety indexes of adverse events Safety indexes of SAE (and 10 more…)	108	Hubei Provincial Center for Disease Control and Prevention Wuhan, Hubei, China
10	Active, not recruiting NEW	A Phase II Clinical Trial to Evaluate the Recombinant Vaccine for COVID-19 (Adenovirus Vector)	COVID-19	Biological: Recombinant novel coronavirus vaccine (Adenovirus type 5 vector) Other: Placebo	Occurrence of adverse reactions Anti SARS-CoV-2 S antibody response(ELISA) Neutralizing antibody response to SARS-CoV-2 (and 3 more…)	500	Hubei Provincial Center for Disease Control and Prevention Wuhan, Hubei, China
11	Not yet recruiting NEW	Evaluating the Safety, Tolerability and Immunogenicity of bacTRL-Spike Vaccine for Prevention of COVID-19	COVID-19	Biological: bacTRL-Spike Other: Placebo	Frequency of Adverse Events SARS-CoV-2 antibodies Incidence of COVID-19 infection (and 3 more…)	84	Vaccine Evaluation Center, BC Children’s Hospital Research Institute, University of British Columbia. Vancouver, British Columbia, Canada Canadian Center for Vaccinology Dalhousie University, IWK Health Centre Halifax, Nova Scotia, Canada
12	Recruiting NEW	COVID-19 and Vaccination Attitudes	COVID-19	Other: Survey	How vaccination and other attitudes are affected by COVID	1000	Survey London, United Kingdom
13	Recruiting NEW	A Study of a Candidate COVID-19 Vaccine (COV001)	Coronavirus	Biological: ChAdOx1 nCoV-19 Biological: MenACWY Biological: ChAdOx1 nCoV-19 boost	Assess efficacy of the candidate ChAdOx1 nCoV-19 against COVID-19: Number of virologically confirmed (PCR positive) symptomatic cases Assess the safety of the candidate vaccine ChAdOx1 nCoV: Occurrence of serious adverse events (SAEs) Assess the safety, tolerability and reactogenicity profile of the candidate vaccine ChAdOx1 nCoV: Occurrence of solicited local reactogenicity signs and symptoms (and 8 more…)	1112	NIHR WTCRF, University Hospital Southampton NHS Foundation Trust Southampton, Hampshire, United Kingdom St Georges University Hospital NHS Foundation Trust London, Tooting, United Kingdom University Hospitals Bristol and Weston NHS Foundation Trust Bristol, United Kingdom (and 3 more…)
14	Recruiting NEW	Study to Determine the Immunization Status Among Nephrological Health Care Personnel Against SARS-CoV-2 in a Single Center Over the Course of 12 Months During the Worldwide COVID-19 Pandemic.	SARS-CoV 2 Immunization; Infection		Status of Immunization	400	Medical University of Vienna, Division for Nephrology and Dialysis Vienna, Austria
15	Not yet recruiting NEW	Experimental Use of Convalescent Plasma for Passive Immunization in Current COVID-19 Pandemic in Pakistan in 2020	Covid-19	Other: convalescent plasma	Change in COVID-19 severity status	2000	Hilton Pharma Pvt. Ltd. Karachi, Sindh, Pakistan
16	Recruiting NEW	Outcome of COVID-19 Cases Based on Tuberculin Test: Can Previous BCG Alter the Prognosis?	COVID-19 BCG Vaccination	Diagnostic Test: Tuberculin test	Pneumonia severity index Need for ICU admission COVID -19 test conversion Mortality	100	AssiutU Assiut, Egypt
17	Not yet recruiting NEW	BCG Vaccine for Health Care Workers as Defense Against SARS-COV2	Coronavirus Coronavirus Infection Coronavirus Sars-Associated as Cause of Disease Classified Elsewhere Coronavirus as the Cause of Diseases Classified Elsewhere	Biological: BCG Vaccine Biological: Placebo Vaccine	incidence (measured by confirmed positive test) of SARS-CoV2 infection following BCG vaccination compared to placebo COVID19-related disease severity (measured by ordinal severity scale) following BCG vaccination compared to placebo	700	Harvard T.H. Chan School of Public Health Boston, Massachusetts, United States Texas A&M University Bryan, Texas, United States Baylor College of Medicine Houston, Texas, United States (and 3 more…)
18	Recruiting	Safety and Immunogenicity Study of 2019-nCoV Vaccine (mRNA-1273) for Prophylaxis SARS CoV-2 Infection (COVID-19)	Corona Virus Infection Immunisations	Biological: mRNA-1273	Frequency of solicited local reactogenicity adverse events (AEs) Frequency of any medically-attended adverse events (MAAEs) Frequency of any new-onset chronic medical conditions (NOCMCs) (and 9 more…)	45	Emory Vaccine Center – The Hope Clinic Decatur, Georgia, United States National Institutes of Health – Clinical Center – Vaccine Research Center Clinical Trials Program Bethesda, Maryland, United States Kaiser Permanente Washington Health Research Institute – Vaccines and Infectious Diseases Seattle, Washington, United States

Daftar Kandidat Vaksin COVID-19 yang Sedang di Uji Klinik di Seluruh Dunia

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